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Description: Talipexole dihydrochloride (also known as B-HT920, Domnin, B-HT-920 dihydrochloride) is a novel and potent dopamine D2 receptor agonist, alpha2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays anti-parkinsonian activity. Talipexole is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim; it was introduced in 1996. As of December 2014 it was not approved for marketing in the US nor in Europe. Talipexole is a D2 dopamine receptor agonist and interacts both pre- and post-synaptic receptors. It also is an alpha2-adrenergic agonist. The main side effects are drowsiness, dizziness, hallucinations and minor gastrointestinal complaints. In 2008 the Japanese Ministry of Health, Labour, and Welfare mandated that Boehringer add a warning to the label concerning the risk of sudden onset of sleep.
References: Gen.Pharmacol. (1999)32 29.
Related CAS #: 36085-73-1 (2HCl); 101626-70-4 (free base)
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