« Back
Home /
azd3147

azd3147

Item no.	V4991-10mg
Manufacturer	InvivoChem LLC
CASRN	1101810-02-9
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4991CAS #:1101810-02-9Purity >=98% Description: AZD3147 is an highly potent and selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 1.5 nM) with physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate. It was identified from a High throughput screening followed by a lead generation campaign which uncovered a novel series of urea containing morpholinopyrimidine compounds which act as potent and selective dual inhibitors of mTORC1 and mTORC2, with improved cellular potency, improved aqueous solubility, and good stability in human hepatocyte incubations. References: J Med Chem. 2015 Mar 12; 58(5):2326-49.
	Name: AZD3147 CAS#: 1101810-02-9 Chemical Formula: C24H31N5O4S2 Exact Mass: 517.18175 Molecular Weight: 517.66 Elemental Analysis: C, 55.68; H, 6.04; N, 13.53; O, 12.36; S, 12.39
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AZD3147; AZD-3147; AZD 3147. IUPAC/Chemical Name: (S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea InChi Key: JWGVUDPAMQEIJU-INIZCTEOSA-N InChi Code: InChI=1S/C24H31N5O4S2/c1-16-15-33-13-11-29(16)21-14-20(24(8-9-24)35(31, 32)19-6-7-19)27-22(28-21)17-2-4-18(5-3-17)26-23(34)25-10-12-30/h2-5, 14, 16, 19, 30H, 6-13, 15H2, 1H3, (H2, 25, 26, 34)/t16-/m0/s1 SMILES Code: S=C(NCCO)NC1=CC=C(C2=NC(N3[CH](C)COCC3)=CC(C4(S(=O)(C5CC5)=O)CC4)=N2)C=C1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer