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tg-100572-hcl

tg-100572-hcl

Item no.	V5008-100mg
Manufacturer	InvivoChem LLC
CASRN	867331-64-4
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5008CAS #:867331-64-4 (HCl)Purity >=98% Description: TG 100572 HCl, the hydrochloride salt of TG 100572, is a novel, potent and selective multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases with IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRbeta, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. By inhibiting Src kinases and selected receptor tyrosine kinases, TG100572 induced apoptosis of proliferating endothelial cells in vitro. TG100572 inhibits downstream molecules involved in the vascular endothelial growth factor (VEGF) signaling pathway resulted in markedly diminished levels of HSV-induced angiogenesis and significantly reduced the severity of SK lesions.. References: J Med Chem. 2008 Mar 27; 51(6):1546-59.; J Cell Physiol. 2008 Jul; 216(1):29-37. Related CAS #: 867331-64-4 (HCl); 867334-05-2 (free base)
	Name: TG100572 HCl CAS#: 867331-64-4 (HCl) Chemical Formula: C26H27Cl2N5O2 Exact Mass: Molecular Weight: 512.435 Elemental Analysis: C, 60.94; H, 5.31; Cl, 13.84; N, 13.67; O, 6.24
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: TG-100572; TG 100572; TG100572; TG-100572 HCl IUPAC/Chemical Name: 4-chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[e][1, 2, 4]triazin-7-yl)phenol hydrochloride InChi Key: NVINBIHNVAYEND-UHFFFAOYSA-N InChi Code: InChI=1S/C26H26ClN5O2.ClH/c1-17-14-18(22-16-20(33)6-9-23(22)27)15-24-25(17)29-26(31-30-24)28-19-4-7-21(8-5-19)34-13-12-32-10-2-3-11-32; /h4-9, 14-16, 33H, 2-3, 10-13H2, 1H3, (H, 28, 29, 31); 1H SMILES Code: CC1=C2C(=CC(=C1)C3=C(C=CC(=C3)O)Cl)N=NC(=N2)NC4=CC=C(C=C4)OCCN5CCCC5.Cl

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Amount: 100 mg

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Delivery expected until 9/4/2025

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