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CBR-5884

CBR-5884

Item no.	V5026-50mg
Manufacturer	InvivoChem LLC
CASRN	681159-27-3
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5026CAS #:681159-27-3Purity >=98% Description: CBR-5884 is a novel, potent, and selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 uM and with anticancer activities. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH. References: Proc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83.
	Name: CBR-5884 CAS#: 681159-27-3 Chemical Formula: C14H12N2O4S2 Exact Mass: 336.0238 Molecular Weight: 336.38 Elemental Analysis: C, 49.99; H, 3.60; N, 8.33; O, 19.02; S, 19.06
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: CBR-5884; CBR 5884; CBR5884. IUPAC/Chemical Name: ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate InChi Key: QBVIRPJBDIZKBC-UHFFFAOYSA-N InChi Code: InChI=1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H, 3H2, 1-2H3, (H, 16, 17) SMILES Code: O=C(C1=CC=CO1)NC2=C(SC#N)C(C)=C(C(OCC)=O)S2

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Amount: 50 mg

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