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Description: ESI-05 (also known as NSC 116966) is a novel, potent and specific antagonist of EPAC2 (exchange protein directly activated by cAMP 2), with an IC50 of 0.4 uM. ESI-05 inhibits cAMP-mediated activation of EPAC2 as well as EAPC2 mediated Rap1 activation.
References: Proc Natl Acad Sci U S A. 2012 Nov 6; 109(45):18613-8.
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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