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Treosulfan (NSC-39069; Treosulphan)

Treosulfan (NSC-39069; Treosulphan)

Item no.	V5077-50mg
Manufacturer	InvivoChem LLC
CASRN	299-75-2
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5077CAS #:299-75-2Purity >=98% Description: Treosulfan (NSC 39069; Treosulphan) is a novel and potent DNA alkylating agent with activity in ovarian cancer and other solid tumor types. Treosulfan is the product of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities. References: Anticancer Res. 2014 Apr; 34(4):1779-84. Related CAS #: 299-75-2 (Treosulfan); 55-98-1 (Busulfan); 52-24-4 (Thiotepa, Girostan; AI3-24916; NSC-6396)
	Name: Treosulfan CAS#: 299-75-2 Chemical Formula: C6H14O8S2 Exact Mass: 278.01301 Molecular Weight: 278.3 Elemental Analysis: C, 25.89; H, 5.07; O, 45.99; S, 23.04
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: NSC 39069; NSC39069; NSC-39069; Treosulphan. Chemical Name: (2S, 3S)-2, 3-dihydroxybutane-1, 4-diyl dimethanesulfonate InChi Key: YCPOZVAOBBQLRI-WDSKDSINSA-N InChi Code: InChI=1S/C6H14O8S2/c1-15(9, 10)13-3-5(7)6(8)4-14-16(2, 11)12/h5-8H, 3-4H2, 1-2H3/t5-, 6-/m0/s1 SMILES Code: O[CH](COS(C)(=O)=O)[CH](O)COS(C)(=O)=O

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Amount: 50 mg

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Delivery expected until 9/4/2025

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