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Description: Fiacitabine(also known as NSC 382097; DRG-0077) is a novel, potent and selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. Fiacitabine is a pyrimidine nucleoside analog reported to elicit potent anti-VZV activity both in vitro and in vivo. Fiacitabine has potent antiviral activity in vivo against herpes simplex virus types 1 and 2 and cytomegalovirus. Fiacitabine is therapeutically superior to ara-A for the treatment of varicella-zoster virus infections in immunosuppressed subjects.
References: J Biol Chem. 1982 Oct 25; 257(20):11879-82.
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