Bruceantin (NCI165563; NSC165563)

InvivoChem Cat #:V5104CAS #:41451-75-6Purity >=98%

Description: Bruceantin (also known as NSC165563), a novel anticancer quassinoid compound extracted from Brucea antidysenterica, is first isolated from Brucea antidysenterica which is a tree found and used in Ethiopia for the treatment of cancer such as leukemia, and the activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.

References: Clin Cancer Res. 2004 Feb 1; 10(3):1170-9.

Related CAS #: 41451-75-6 (Bruceantin); 79439-84-2 (Bruceantinoside B); 95258-15-4 (Yadanzioside A); 95258-18-7 (Yadanzioside B); 95258-16-5 (Yadanzioside C)

-20C for 3 years in powder form

Synonym: (-)-Bruceantin; NCI165563; NCI-165563; NCI 165563; NSC165563; NSC-165563; NSC 165563;
Chemical Name: Picras-3-en-21-oic acid, 15-((3, 4-dimethyl-1-oxo-2-pentenyl)oxy)-13, 20-epoxy-3, 11, 12-trihydroxy-2, 16-dioxo-, methyl ester, (11beta, 12alpha, 15beta(E))- (9CI)
InChi Key: IRQXZTBHNKVIRL-GOTQHHPNSA-N
InChi Code: InChI=1S/C28H36O11/c1-11(2)12(3)7-17(30)39-20-22-27-10-37-28(22, 25(35)36-6)23(33)19(32)21(27)26(5)9-15(29)18(31)13(4)14(26)8-16(27)38-24(20)34/h7, 11, 14, 16, 19-23, 31-33H, 8-10H2, 1-6H3/b12-7+/t14-, 16+, 19+, 20+, 21+, 22+, 23-, 26-, 27+, 28-/m0/s1
SMILES Code: CC([C](C[C](O1)2[H])3[H])=C(O)C(C[C]3(C)[C]4([H])[C]2(CO[C]5([CH](O)[CH]4O)C(OC)=O)[C]5([H])[CH](OC(/C=C(C)/C(C)C)=O)C1=O)=O