Mc-Val-Cit-PABC-PNP

InvivoChem Cat #:V5176CAS #:159857-81-5Purity >=98%

Description: Mc-Val-Cit-PABC-PNP (Mc-Val-Cit-PABC-PNP) is a cathepsin cleavable ADC peptide linker used in the synthesis of antibody-drug conjugates (ADCs). The mechanism is like this: the Val-Cit will specifically be cleaved by catepsin B as this enzyme is only present in the lysosome, the ADC warhead/payload (the drug) will be released in the cell. The Azido group will react with DBCO, BCN or other Alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

References: https://patents.google.com/patent/US20080025989

Related CAS: 159857-80-4 (MC-Val-Cit-PAB); 159857-79-1 (Val-cit-PAB-OH); 159857-81-5 (MC-Val-Cit-PAB-PNP)

-20C for 3 years in powder form

Synonym: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate; MC-Val-Cit-PAB-PNP; Mc-Val-Cit-PABC-PNP; Mc-Val-Cit-PAB
Chemical Name: 4-((S)-N-((S)-1-amino-1-oxo-5-ureidopentan-2-yl)-2-(6-(2, 5-dioxo-2, 5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)benzyl (4-nitrophenyl) carbonate
InChi Key: UQRQGHMQKAXOTE-DHIFEGFHSA-N
InChi Code: InChI=1S/C35H43N7O11/c1-22(2)31(39-28(43)8-4-3-5-20-40-29(44)17-18-30(40)45)33(47)41(27(32(36)46)7-6-19-38-34(37)48)24-11-9-23(10-12-24)21-52-35(49)53-26-15-13-25(14-16-26)42(50)51/h9-18, 22, 27, 31H, 3-8, 19-21H2, 1-2H3, (H2, 36, 46)(H, 39, 43)(H3, 37, 38, 48)/t27-, 31-/m0/s1
SMILES Code: O=C([CH](NC([CH](NC(CCCCCN1C(C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O)NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O