Comparison

Olutasidenib (FT2102)

Item no. V5193-100mg
Manufacturer InvivoChem LLC
CASRN 1887014-12-1
Amount 100 mg
Quantity options 10 mg 25 mg 50 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V5193CAS #:1887014-12-1 Purity >=98%

Description: Olutasidenib (FT-2102) is a novel, highly potent and selective small molecue inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1) with the potential to be used in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Isocitrate dehydrogenase 1 mutations (IDH1m) occur in 7-14% of AML patients (pts) and 3% of MDS pts. FT-2102 has shown favorable safety, PK/PD, and clinical activity in IDH1m AML/MDS with a single agent complete response rate (CR/CRi) of 38% and a complete response rate of 27% in combination with AZA. Current data support the continued evaluation of 150 mg BID in the expansion and Phase 2 stages of the study.

References: A phase 1 dose escalation study of the IDH1m inhibitor, FT-2102, in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Olutasidenib

Name: Olutasidenib
CAS#: 1887014-12-1
Chemical Formula: C18H15ClN4O2
Exact Mass: 354.0884
Molecular Weight: 354.794
Elemental Analysis: C, 60.94; H, 4.26; Cl, 9.99; N, 15.79; O, 9.02
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Technical Information
Synonym: FT-2102; FT 2102; FT2102
Chemical Name: 5-[[(1S)-1-(6-Chloro-2-oxo-1, 2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1, 6-dihydropyridine-2-carbonitrile
InChi Key: NEQYWYXGTJDAKR-JTQLQIEISA-N
InChi Code: InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)23(2)18(16)25)14-8-11-7-12(19)3-5-15(11)22-17(14)24/h3-8, 10, 21H, 1-2H3, (H, 22, 24)/t10-/m0/s1
SMILES Code: N#CC1=CC=C(N[CH](C2=CC3=C(NC2=O)C=CC(Cl)=C3)C)C(N1C)=O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
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