Comparison

elenbecestat

Item no. V5256-100mg
Manufacturer InvivoChem LLC
CASRN 1388149-39-0
Amount 100 mg
Quantity options 10 mg 25 mg 50 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V5256CAS #:1388149-39-0Purity >=98%

Description: Elenbecestat (E2609) is a novel, potent orally bioactive and BBB-penetrant BACE1 inhibitor which can reduce the plasma beta-amyloid levels after single dosing and has the potential for the treatment of Alzheimer's disease (AD). By inhibiting BACE, a key enzyme in the production of Abeta peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain.

References: Eur J Med Chem. 2018 Mar 25; 148:436-4

Elenbecestat

Name: Elenbecestat
CAS#: 1388149-39-0
Chemical Formula: C19H15F6N5O2S
Exact Mass: 491.0851
Molecular Weight: 491.4124
Elemental Analysis: C, 46.44; H, 3.08; F, 23.20; N, 14.25; O, 6.51; S, 6.52
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Technical Information
Synonym: E2609; E-2609; E 2609.
Chemical Name: N-(3-((4aS, 5S, 7aS)-2-amino-5-(trifluoromethyl)-4a, 5-dihydro-4H-furo[3, 4-d][1, 3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
InChi Key: ZKKFSFUYHYWFFE-FWVNDXEPSA-N
InChi Code: InChI=1S/C19H15F6N5O2S/c20-11-2-1-8(29-16(31)13-5-27-12(4-28-13)15(21)22)3-9(11)18-7-32-14(19(23, 24)25)10(18)6-33-17(26)30-18/h1-5, 10, 14-15H, 6-7H2, (H2, 26, 30)(H, 29, 31)/t10-, 14+, 18-/m1/s1
SMILES Code: FC(F)C1=CN=C(C(NC2=CC=C(F)C([C]3(CO[CH]4C(F)(F)F)[C]4([H])CSC(N)=N3)=C2)=O)C=N1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
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