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Description: Photo-lysine HCl is a novel lysine-based photo-reactive amino acid, which captures proteins that bind lysine post-translational modifications. Post-translational modifications (PTMs) have key roles in regulating protein-protein interactions in living cells. However, it remains a challenge to identify these PTM-mediated interactions. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine PTMs, including 'readers' and 'erasers' of histone modifications.
References: Nat Chem Biol. 2016 Feb; 12(2):70-2.
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