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Description: NE10790, an analog of risedronate, is a poor farnesyl pyrophosphate synthase inhibitor and a weak antiresorptive agent. It belongs to the group of phosphonocarboxylates in which one of the phosphonate groups is substituted by a carboxyl group. NE-10790 had strongly reduced binding affinity, but still retained some antiresorptive activity. The group of phosphonocarboxylates, with strongly reduced bone affinity, provides an interesting therapeutic option.
References: J Biol Chem. 2001 Dec 21; 276(51):48213-22.
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