GTS-21 HCl

Description: GTS-21, formerly known as DMBX-A, is a analogue of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the alpha4beta2 and alpha7 subtypes, but activates only the alpha7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.

References: Yue Y, Liu R, Cheng W, Hu Y, Li J, Pan X, Peng J, Zhang P. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-kappaB signaling pathway through the alpha7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Oct 17. pii: S1567-5769(15)30138-7. doi: 10.1016/j.intimp.2015.10.005. Epub ahead of print PubMed PMID: 26490221.