Aclarubicin hydrochloride (Aclacinomycin A)

Description: Aclarubicin (Aclacinomycin A) is a novel, potent and natually occuring oligosaccharide anthracycline antineoplastic antibiotic extracted from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.

References: Shin DH, Choi KS, Park SA, Cho BS, Lee HS, Ryu JS, Kim TY, Lee CK, Song S, Chung YB. Extensive intracellular accumulation of ID-6105, a novel anthracycline, in SK-OV-3 ovarian cancer cells. Arch Pharm Res. 2008 Oct; 31(10):1355-61. Epub 2008 Oct 29. PubMed PMID: 18958428.

Related CAS #: 75443-99-1 (HCl); 57576-44-0 (free base)