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BCI hydrochloride

BCI hydrochloride

Item no.	V5934-50mg
Manufacturer	InvivoChem LLC
CASRN	95130-23-7
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5934CAS #:95130-23-7Purity >=98% Description: BCI hydrochloride (E)-BCI is a novel, potent and allosteric inhibitor of Dusp6 (dual specificity phosphatase), which acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. It inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 uM in cells, respectively. References: Wu QN, Liao YF, Lu YX, Wang Y, Lu JH, Zeng ZL, Huang QT, Sheng H, Yun JP, Xie D, Ju HQ, Xu RH. Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance. Cancer Lett. 2018 Jan 1; 412:243-255. doi: 10.1016/j.canlet.2017.10.007. Epub 2017 Oct 16. PubMed PMID: 29050982. Related CAS #: 15982-84-0 (free base) 95130-23-7 (HCl)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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