padeliporfin-wst-11

Description: Padeliporfin, formerly known as WST-11, is vascular-acting photosensitizer consisting of a water-soluble, palladium-substituted bacteriochlorophyll analogue with potential antineoplastic activity. Upon administration, paldeliporfin is activated locally when the tumor bed is exposed to low-power laser light; reactive oxygen species (ROS) are formed upon activation and ROS-mediated necrosis may occur at the site of interaction between the photosensitizer, light and oxygen. Vascular-targeted photodynamic therapy (VTP) with padeliporfin may allow tumor-site specific cytotoxicity while sparing adjacent normal tissues. (NCI Thesaurus).

References: Kessel D, Price M. Evaluation of DADB as a Probe for Singlet Oxygen Formation during Photodynamic Therapy. Photochem Photobiol. 2012 Feb 2. doi: 10.1111/j.1751-1097.2012.01106.x. Epub ahead of print PubMed PMID: 22296586.