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Description: BMS-199264 hydrochloride is a novel and potent inhibitor of the ATP hydrolase activity of mitochondrial F1F0 ATP synthase. It has no affect on the ATP synthase function of F1F0. In isolated rat hearts, BMS-199624 blocks depletion of ATP levels, and blocks necrosis during ischemia. BMS-191264 decreases cardiac necrosis and improves the recovery of contractile activities after reperfusion.
Refrences: Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia.
Related CAS #: 675833-20-2 (free base) 186180-83-6 (HCl)
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