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Description: 3BDO is a butyrolactone analog which acts as a mTOR activator, it targets FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs.
References:
1. GeD, et al. Identification of a novel MTOR activator and discovery of acompeting endogenous RNA regulating autophagy in vascular endothelialcells. Autophagy. 2014 Jun; 10(6):957-71.
2. PengN, et al. An activator of mTOR inhibits oxLDL-induced autophagy andapoptosis in vascular endothelial cells and restricts atherosclerosis inapolipoprotein E?/? mice. Sci Rep. 2014 Jul 1; 4:5519.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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