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Description: SRI37892 is a frizzled-7 (Fzd7) inhibitor which inhibits LRP6 phosphorylation, downregulates the level of cytosolic free beta-catenin, and functionally represses breast cancer cell viability and colony formation. SRI37892 targets the transmembrane domain of FZD7, thereby blocking the WNT signal transmission.
References: Zhang W, Lu W, Ananthan S, Suto MJ, Li Y. Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain. Oncotarget. 2017 Sep 6; 8(53):91459-91470. doi: 10.18632/oncotarget.20665. eCollection 2017 Oct 31. PubMed PMID: 29207657; PubMed Central PMCID: PMC5710937.
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