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Description: TCN-201 is a novel, potent, non-competitive and selective antagonist of NMDA receptors containing the NR2A subunit with a pIC50 of 6.8. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
References: Müller SL, Schreiber JA, Schepmann D, Strutz-Seebohm N, Seebohm G, Wünsch B. Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201. Eur J Med Chem. 2017 Mar 31; 129:124-134. doi: 10.1016/j.ejmech.2017.02.018. Epub 2017 Feb 14. PubMed PMID: 28222314.
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