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Anti-Crotonyllysine Antibody Conjugated Agarose Beads

Anti-Crotonyllysine Antibody Conjugated Agarose Beads

Item no.	PTM-503
Manufacturer	PTM Biolabs
Amount	500 ul
Category	Reagents & Chemicals Nanoparticles Beads & Resins
Type	Antibody Conjugated Beads
Format	Liquid
Applications	IA
Specific against	other
Isotype	IgG
Conjugate/Tag	Agarose
Dry ice	Yes
Citations	Wen-Li Gao, et al. The faucet knob effect of DptE crotonylation on the initial flow of daptomycin biosynthesis. METABOLIC ENGINEERING, 2024. https://www.sciencedirect.com/science/article/pii/S1096717624001459.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	41105507
Alias	Kcr
Shipping Condition	Dry ice
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Applications	IAP
Manufacturer - Category	Pan PTM Antibodies
Shipping Temperature	Cold packs / dry ice
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	Multiple
Stability	Stable for 12 months from date of receipt.
Manufacturer - Research Area	Post-Translational Modificaiton
Manufacturer - Reactivity	All
Product description	Lysine crotonylation is a newly-identified histone post-translational modification by integrated proteomic approaches and elaborate biochemistry analyses. It has been shown that lysine crotonylation is an evolutionarily conserved PTM in multiple species of both prokaryotes and eukaryotes in a wide range of proteins, both in histones and non-histone substrates. The unique structure and genomic localization of lysine crotonylation suggest that it is mechanistically and functionally different from lysine acetylation. Given the revealed roles of lysine crotonylation in spermatogenesis, the novel modification may play important roles in multiple cellular pathophysiological processes by effecting chromatin structure and epigenetic pathways.
Manufacturer - Specificity	With a mixture of high-quality rabbit- and mouse-derived anti-crotonyllysine antibodies cross-linked, this Anti-Crotonyllysine Antibody Conjugated Agarose Beads present extraordinary capability to specifically capture peptides/proteins bearing crotonyllysine residues but do not cross-react with the peptides/proteins bearing structurally similar acetyllysine residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine crotonylation.
Formula	Antibody conjugated agarose beads are supplied as a 50% slurry containing 66% glycerol and 4 mg/ml immobilized antibody.
PTM	Crotonyl
Modification Site	Lys
Immunogen	Crotonylated lysine peptides
Clonality	Polyclonal/Monoclonal
Background	Lysine crotonylation is a newly-identified histone post-translational modification by integrated proteomic approaches and elaborate biochemistry analyses. It has been shown that lysine crotonylation is an evolutionarily conserved PTM in multiple species of both prokaryotes and eukaryotes in a wide range of proteins, both in histones and non-histone substrates. The unique structure and genomic localization of lysine crotonylation suggest that it is mechanistically and functionally different from lysine acetylation. Given the revealed roles of lysine crotonylation in spermatogenesis, the novel modification may play important roles in multiple cellular pathophysiological processes by effecting chromatin structure and epigenetic pathways.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ul

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Delivery expected until 11/27/2025

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