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Anti-Malonyllysine Antibody Conjugated Agarose Beads

Anti-Malonyllysine Antibody Conjugated Agarose Beads

Item no.	PTM-904
Manufacturer	PTM Biolabs
Amount	500 ul
Category	Reagents & Chemicals Nanoparticles Beads & Resins
Type	Antibody Conjugated Beads
Format	Liquid
Applications	IA
Specific against	other
Isotype	IgG
Conjugate/Tag	Agarose
Dry ice	Yes
Citations	Liang Sun, et al. Nucleolin Malonylation as a Nuclear-Cytosol Signal Exchange Mechanism to Drive Cell Proliferation in Hepatocarcinoma by Enhancing AKT Translation. JOURNAL OF BIOLOGICAL CHEMISTRY, 2024. https://www.sciencedirect.com/science/article/pii/S0021925824022865.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	41105507
Alias	Kmal
Shipping Condition	Dry ice
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Applications	IAP
Manufacturer - Category	Pan PTM Antibodies
Shipping Temperature	Cold packs / dry ice
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	Multiple
Stability	Stable for 12 months from date of receipt.
Manufacturer - Research Area	Post-Translational Modificaiton
Manufacturer - Reactivity	All
Product description	Malonylation of lysine is a newly identified reversible modification controlling protein activity. Sirt5, a regulatory enzyme for lysine malonylation, can catalyze lysine demalonylation reactions in vivo and in vitro. Through integrated proteomic approaches and biochemistry analysis, it has been found that lysine malonylation is widely distributed acrossvarious histones and non-histone substrates. Lysine malonylation may provide a new paradigm in cellular regulation, such as energy metabolism in diverse organisms.
Manufacturer - Specificity	With a mixture of high-quality rabbit- and mouse-derived anti-malonyllysine antibodies cross-linked, this Anti-Malonyllysine Antibody Conjugated Agarose Beads present extraordinary capability to specifically capture peptides/proteins bearing phosphotyrosine residues but do not cross-react with the peptides/proteins bearing structurally similar succinyllysine, propionyllysine, or butyryllysine residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine malonylation.
Formula	Antibody conjugated agarose beads are supplied as a 50% slurry containing 66% glycerol and 4 mg/ml immobilized antibody.
PTM	Malonyl
Modification Site	Lys
Immunogen	Malonylated lysine peptides
Clonality	Polyclonal/Monoclonal
Background	Malonylation of lysine is a newly identified reversible modification controlling protein activity. Sirt5, a regulatory enzyme for lysine malonylation, can catalyze lysine demalonylation reactions in vivo and in vitro. Through integrated proteomic approaches and biochemistry analysis, it has been found that lysine malonylation is widely distributed acrossvarious histones and non-histone substrates. Lysine malonylation may provide a new paradigm in cellular regulation, such as energy metabolism in diverse organisms.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ul

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Delivery expected until 11/27/2025

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