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NGF-beta

NGF-beta

Item no.	RLT-100-084S
Manufacturer	ReliaTech
Amount	5ug
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Hamster, Chicken (Gallus gallus domesticus)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	NGF, NGFB, HSAN5, Beta-NGF
Available
NCBI Gene ID	4803
Uniprot	P01138
Biological Activity	Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is = 1.0 ng/ml, corresponding to a specific activity of = 1 x 106 units/mg.
Description	ß-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. ß-NGF is a potent neurotrophic factor that signals through its receptor ß-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. ß-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human ß-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	240
Molecular Weight	13.5 kDa
mRNA RefSeq	NM_002506
Protein RefSeq	NP_002497.2
Protein Sequence	SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
Purity Confirmation	> 98% by SDS-PAGE & HPLC analysis
Synonyms	NGF; NGFB; HSAN5; Beta-NGF
Uniprot ID	P01138

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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