IL-11

Item no.	RLT-100-050
Manufacturer	ReliaTech
Amount	10ug
Category	Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins Obesity
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Monkey (Cynomolgus, Simian), Bacteria (generic)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	IL11, AGIF, IL-11
Available
NCBI Gene ID	3589
Uniprot	P20809
Biological Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is = 2.0 ng/ml, corresponding to a specific activity of = 5 x 105 units/mg.
Description	IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	179
Molecular Weight	19.1 kDa
mRNA RefSeq	NM_000641
Protein RefSeq	NP_000632.1
Protein Sequence	MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	IL11; AGIF; IL-11
Uniprot ID	P20809

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