IL-12

Item no.	RLT-100-051S
Manufacturer	ReliaTech
Amount	2ug
Category	Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Monkey (Cynomolgus, Simian)
Host	CHO cells
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	IL12A, P35, CLMF, NFSK, NKSF1, IL-12A
Available
NCBI Gene ID	3592
Uniprot	P29459
Biological Activity	The ED50 was determined by the induction of IFN-? from NK cells co-stimulated with IL-18 is = 1.0 ng/ml, corresponding to a specific activity of = 1 x 106 units/mg.
Description	IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	503
Molecular Weight	75 kDa
mRNA RefSeq	NM_000882.3
Protein RefSeq	NP_000873.2
Protein Sequence	p35 Subunit: RNLPVA TPDPGMFPCL HHSQNLLRAV SNMLQKARQT LEFYPCTSEE IDHEDITKDK TSTVEACLPL ELTKNESCLN SRETSFITNG SCLASRKTSF MMALCLSSIY EDLKMYQVEF KTMNAKLLMD PKRQIFLDQN MLAVIDELMQ ALNFNSETVP QKSSLEEPDF YKTKIKLCIL LHAFRIRAVT IDRVMSYLNA S p40 Subunit: IWELKK DVYV
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	IL12A; P35; CLMF; NFSK; NKSF1; IL-12A
Uniprot ID	P29459

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