GDF-3

Item no.	RLT-100-179S
Manufacturer	ReliaTech
Amount	5ug
Category	Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	GDF3, KFS3, MCOP7, MCOPCB6
Available
NCBI Gene ID	9573
Uniprot	Q9NR23
Biological Activity	Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
Description	GDF-3 is a member of the TGF-ß superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-ß family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	114
Molecular Weight	26 kDa
mRNA RefSeq	NM_020634
Protein RefSeq	NP_065685.1
Protein Sequence	AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	GDF3; KFS3; MCOP7; MCOPCB6
Uniprot ID	Q9NR23

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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