IL-12

Item no.	RLT-M10-021
Manufacturer	ReliaTech
Amount	10ug
Category	Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	CHO cells
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	Il12a, p35, Ll12a, Il-12a, IL-12p35
Available
NCBI Gene ID	16159
Uniprot	P43431
Biological Activity	Assay #1: The ED50 was determined by the stimulation of IFN-gamma production by murine splenocytes co-stimulated with IL-18 is < 0.1 ng/ml (> 1 x 107 units/mg). Assay #2: Determined by its ability to stimulate the proliferation of 2D6 cells. The expected ED50 is =0.1ng/ml (=1 x 107 units/mg).
Description	Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	506
Molecular Weight	75 kDa
mRNA RefSeq	NM_001159424.1
Protein RefSeq	NP_001152896.1
Protein Sequence	p35 Subunit: RVIPVSGPAR CLSQSRNLLK TTDDMVKTAR EKLKHYSCTA EDIDHEDITR DQTSTLKTCL PLELHKNESC LATRETSSTT RGSCLPPQKT SLMMTLCLGS IYEDLKMYQT EFQAINAALQ NHNHQQIILD KGMLVAIDEL MQSLNHNGET LRQKPPVGEA DPYRVKMKLC ILLHAFSTRV VTINRVMGYL SSA p40 Subunit: MWELEKDVYV VEVDW
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	Il12a; p35; Ll12a; Il-12a; IL-12p35
Uniprot ID	P43431

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