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NGF-beta

NGF-beta

Item no.	RLT-M10-123
Manufacturer	ReliaTech
Amount	100ug
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	Ngf, Ngfb
Available
NCBI Gene ID	18049
Uniprot	P01139
Biological Activity	The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is = 1.0 ng/ml, corresponding to a specific activity of = 1 x 106 units/mg.
Description	ß-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. ß-NGF is a potent neurotrophic factor that signals through its receptor ß-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. ß-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of murine ß-NGF is a noncovalently disulfide-linked homodimer, of two 13.4 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	240
Molecular Weight	13.4 kDa
mRNA RefSeq	NM_013609
Protein RefSeq	NP_038637.1
Protein Sequence	SSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINNSVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL TTDEKQAAWR FIRIDTACVC VLSRKATRRG
Purity Confirmation	> 98% by SDS-PAGE & HPLC analysis
Synonyms	Ngf; Ngfb
Uniprot ID	P01139

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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