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Nesfatin

Nesfatin

Item no.	RLT-100-142S
Manufacturer	ReliaTech
Amount	20ug
Category	Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	Nesfatin, Nucleobindin 2 protein
Available
NCBI Gene ID	4925
Uniprot	P80303
Biological Activity	Determined by an in vivo assay using healthy wild type male mice (C57BL/6J). Mice were treated via intraperitoneal injection once at a dose of 4µg Nesfatin-1/gm of body weight. Significant effects on body weight and food consumption were observed relative to saline-treated controls.
Description	Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Originally identified as a hypothalamic neuropeptide, Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic isletsß-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Recombinant human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	82
Molecular Weight	9.7 kDa
mRNA RefSeq	NM_005013.2
Protein RefSeq	NP_005004
Protein Sequence	VPIDIDKTKV QNIHPVESAK IEPPDTGLYY DEYLKQVIDV LETDKHFREK LQKADIEEIK SGRLSKELDL VSHHVRTKLD EL
Purity Confirmation	> 98% by SDS-PAGE & HPLC analysis
Synonyms	Nesfatin, Nucleobindin 2 protein
Uniprot ID	P80303

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