IL-17E

Item no.	RLT-100-227
Manufacturer	ReliaTech
Amount	25ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	IL25, IL17E
Available
NCBI Gene ID	64806
Uniprot	Q9H293
Biological Activity	Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100ng.
Description	IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NK-kB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	145
Molecular Weight	33.8 kDa
mRNA RefSeq	NM_022789
Protein RefSeq	NP_073626.1
Protein Sequence	MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	IL25; IL17E
Uniprot ID	Q9H293

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