IL-31

Item no.	RLT-100-232S
Manufacturer	ReliaTech
Amount	2ug
Category	Oncology Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines By Organ Skin Cancer Hepatic Cancer
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	IL31, IL-31
Available
NCBI Gene ID	386653
Uniprot	Q6EBC2
Biological Activity	Measured by its ability to induce STAT3 activation in human U87 cells.
Description	Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	141
Molecular Weight	15.8 kDa
mRNA RefSeq	NM_001014336.1
Protein RefSeq	NP_001014358.1
Protein Sequence	SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	IL31; IL-31
Uniprot ID	Q6EBC2

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