ICAM-1

Item no.	RLT-100-341S
Manufacturer	ReliaTech
Amount	10ug
Category	Oncology Neuroscience Neural Lineage Markers By Cell Type Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Bacteria (generic)
Host	CHO cells
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	ICAM1, BB2, CD54, P3.58
Available
NCBI Gene ID	3383
Uniprot	P05362
Biological Activity	ICAM-1 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25µg/ml ICAM-1 concentration.
Description	ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain. Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	453
Molecular Weight	49.5 kDa
mRNA RefSeq	NM_000201
Protein RefSeq	NP_000192.2
Protein Sequence	QTSVSPSKVI LPRGGSVLVT CSTSCDQPKL LGIETPLPKK ELLLPGNNRK VYELSNVQED SQPMCYSNCP DGQSTAKTFL TVYWTPERVE LAPLPSWQPV GKNLTLRCQV EGGAPRANLT VVLLRGEKEL KREPAVGEPA EVTTTVLVRR DHHGANFSCR TELDLRPQGL ELFENTSAPY QLQTFVLPAT PPQLVSPRVL EVDTQGTVVC SLDGLFPVSE AQVHLALGDQ RL
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	ICAM1; BB2; CD54; P3.58
Uniprot ID	P05362

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