MMP-2

Item no.	RLT-100-372
Manufacturer	ReliaTech
Amount	10ug
Category	Oncology Neuroscience Neuroinflammation Aging & Neurological Disorders By Cell Type Blastoma Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	MMP2, CLG4, MONA, CLG4A, TBE-1, MMP-II
Available
NCBI Gene ID	4313
Uniprot	P08253
Biological Activity	MMP-2 activity was measured by its ability to cleave a chromogenic peptide MMP-2 substrate at room temperature. At an MMP-2 concentration of 2.5 µg/ml, 50% cleavage was achieved at an incubation time of approximately 25 minutes.
Description	Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids).
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	552
Molecular Weight	62 kDa
mRNA RefSeq	NM_004530
Protein RefSeq	NP_004521.1
Protein Sequence	MYNFFPRKPK WDKNQITYRI IGYTPDLDPE TVDDAFARAF QVWSDVTPLR FSRIHDGEAD IMINFGRWEH GDGYPFDGKD GLLAHAFAPG TGVGGDSHFD DDELWTLGEG QVVRVKYGNA DGEYCKFPFL FNGKEYNSCT DTGRSDGFLW CSTTYNFEKD GKYGFCPHEA LFTMGGNAEG QPCKFPFRFQ GTSYDSCTTE GRTDGYRWCG TTEDYDRDKK YGFCPETAMS TV
Purity Confirmation	> 90% by SDS-PAGE & HPLC analyses
Synonyms	MMP2; CLG4; MONA; CLG4A; TBE-1; MMP-II
Uniprot ID	P08253

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