CDNF

Item no.	RLT-100-400S
Manufacturer	ReliaTech
Amount	5ug
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	cerebral dopamine neurotrophic factor, ARMETL1
Available
NCBI Gene ID	1270
Uniprot	Q49AH0
Biological Activity	Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 µg/ml.
Description	CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	162
Molecular Weight	18.5 kDa
mRNA RefSeq	NM_001029954
Protein RefSeq	NP_001025125
Protein Sequence	MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GAT kDaATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	cerebral dopamine neurotrophic factor, ARMETL1
Uniprot ID	Q49AH0

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