MIF

Item no.	RLT-100-418S
Manufacturer	ReliaTech
Amount	5ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Peptides & Proteins Recombinant Proteins By Organ Lung Cancer Colorectal Cancer Breast Cancer
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	Insect Cells
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	Macrophage migration Inhibitory factor, GLIF, MMIF, GIF, Glycosylation-inhibiting factor
Available
NCBI Gene ID	4282
Uniprot	P14174
Biological Activity	Determined by its ability to inhibit monocyte migration.
Description	Macrophage Migration Inhibitory Factor (MIF) is a small secreted protein that can act as a pleiotropic pro-inflammatory cytokine as well as an enzyme. MIF pro-inflammatory activity can be initiated by signaling through CD74 and CD44, resulting in the secretion of TNF-a, IL-1, IL-6, IL-8, and various MMPs. The enzymatic activity of MIF is characterized by its ability to act as a tautomerase, capable of catalyzing the keto to enol isomerization of keto-phenylpyruvate and L-dopachrome. It appears as though MIF catalytic activity is dependent upon a trimeric configuration and a free N-terminal proline residue. Insect cell derived recombinant MIF is a 15 kDa protein containing 124 amino acid residues, including an N-terminal His-tag.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Label	His-Tag
Length [aa]	124
Molecular Weight	15 kDa
mRNA RefSeq	NM_002415.1
Protein RefSeq	NP_002406.1
Protein Sequence	HHHHHHHHAM PMFIVNTNVP RASVPDGFLS ELTQQLAQAT GKPPQYIAVH VVPDQLMAFG GSSEPCALCS LHSIGKIGGA QNRSYSKLLC GLLAERLRIS PDRVYINYYD MNAANVGWNN STFA
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	Macrophage migration Inhibitory factor, GLIF, MMIF, GIF, Glycosylation-inhibiting factor
Uniprot ID	P14174

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