PAF-AH

Item no.	RLT-100-423
Manufacturer	ReliaTech
Amount	20ug
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Enzymes Fatty Acid Catabolism
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	HEK293
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	PAF-acetylhydrolase, PAF 2-acylhydrolase, LDL-PLA82), 2-acetyl-1-alkylglycerophosphacholine esterase
Available
NCBI Gene ID	5049
Uniprot	P68402
Biological Activity	Measured by its ability to cleave a PAF analog in a chromogenic substrate linked assay. At a PAF-AH concentration of 10.0 µg/ml, 50% cleavage was achieved at an incubation time of approximately 2 minutes.
Description	Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet Activating Factor Acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the “sn2” ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids. Recombinant PAF-AH is a 420 amino acid glycoprotein which migrates with an apparent molecular mass of 47-55 kDa by SDS-PAGE analysis.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	420
Molecular Weight	47-55 kDa
mRNA RefSeq	NM_002572.3
Protein RefSeq	NP_002563.1
Protein Sequence	FDWQYINPVA HMKSSAWVNK IQVLMAAASF GQTKIPRGNG PYSVGCTDLM FDHTNKGTFL RLYYPSQDND RLDTLWIPNK EYFWGLSKFL GTHWLMGNIL RLLFGSMTTP ANWNSPLRPG EKYPLVVFSH GLGAFRTLYS AIGIDLASHG FIVAAVEHRD RSASATYYFK DQSAAEIGDK SWLYLRTLKQ EEETHIRNEQ VRQRAKECSQ ALSLILDIDH GKPVKNALDL KF
Purity Confirmation	> 95% by SDS-PAGE & HPLC analyses
Synonyms	PAF-acetylhydrolase, PAF 2-acylhydrolase, LDL-PLA82), 2-acetyl-1-alkylglycerophosphacholine esterase
Uniprot ID	P68402

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 20ug

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Delivery expected until 8/21/2025

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