IL-2

3558

The ED50 as determined by the dose-dependent stimulation of proliferation of murine D10G4.1 cells is in the range of 0.1-0.5 ng/ml.

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 (modified at the C-terminal end) is a 15.5 kDa protein, containing 156 amino acid residues including one intrachain disulfide bond.

156

NM_000586

NP_000577

> 98% by SDS-PAGE & visualized by silver stain

The lyophilized IL-2, though stable at room temperature, is best stored desiccated below 0 °C. Reconstituted IL-2 should be stored in workingaliquots at -20 °C. Avoid repeated freeze-thaw cycles.

P60568