IL-33

Item no.	RLT-M10-241S
Manufacturer	ReliaTech
Amount	2ug
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Neurodegeneration Markers Glial Cell Markers
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Mouse (Murine, Mus musculus)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	NF-HEV
Available
NCBI Gene ID	77125
Uniprot	Q8BVZ5
Biological Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is = 0.5 ng/ml, corresponding to a specific activity of = 2 x 106units/mg.
Description	IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant murine IL-33 is a 17.5 kDa protein containing 158 amino acid residues.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	158
Molecular Weight	17.5 kDa
mRNA RefSeq	NM_133775.2
Protein RefSeq	NP_598536.2
Protein Sequence	SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	NF-HEV
Uniprot ID	Q8BVZ5

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