Human CD32b (Luc) Jurkat Reporter Cell

• Determination of ADCP activity induced by antibodies.

Luc

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Fcγ receptors (FcγRs), the largest group of FcRs, bind IgG and comprise several subtypes. Low- affinity FcγRs , including two activating receptors (FcγRIIIa (CD16A) and FcγRIIa (CD32A)) and a inhibitory receptor(FcγRIIb (CD32B)), are important mediators of antibody functions in vivo, including antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and induction of cytokines and chemokines. The inhibitory receptor, FcγRIIb (CD32B), contains an immunoreceptor tyrosine-based inhibition motif that counters cell activation when inhibitory and activating receptors become co-engaged.

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