THZ1

Item no.	TMO-T3664-5mg
Manufacturer	TargetMol
CASRN	1604810-83-4
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Kwiatkowski N, et al. Nature. 2014 Jul 31;511(7511):616-20.;Nilson KA, et al. Mol Cell. 2015 Aug 20;59(4):576-87.;
Smiles	CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	THZ1 2HCl,CDK7 inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	CDK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	566.05
Description	THZ1 (CDK7 inhibitor) is a selective covalent inhibitor of CDK7, exhibiting binding affinity to the cysteine residue located at the outer end of the classical kinase domain, thus conferring high selectivity for CDK7, with an IC50 of 3.2 nM.
Pathways	Cell Cycle/Checkpoint

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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