KD-026

Item no.	TMO-T27719-2mg
Manufacturer	TargetMol
CASRN	913541-47-6
Amount	2 mg
Specific against	other
Smiles	COc1cccc(C(=O)Nc2ccc3CN(CCc3c2)C(=O)Oc2ccccc2)c1-c1ccc(cc1)C(F)(F)F
Alias	SLx 4090, SLx4090, SLx-4090, KD026
Shipping condition	Cool pack
Available
Manufacturer - Targets	STAT
Shipping Temperature	cool pack
Storage Conditions	-20°
Description	W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis and effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. It mitigates chemoresistance to 5-FU in cancer cells and modulates the cell cycle, DNA damage response, and oxidative phosphorylation, targeting pathways such as IL6-JAK-STAT3 and ferroptosis [1].
Pathways	Stem Cells\|\|\|JAK/STAT signaling

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