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Genistein 7-Sulfate Sodium Salt

Genistein 7-Sulfate Sodium Salt

Item no.	TRC-G350045-2,5mg
Manufacturer	Toronto Research Chemicals
Amount	2,5mg
Category	Oncology
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Mol. Formula	C15H9NaO8S
Mol. Weight	372, 28
Subcategory	Inhibitors, Tyrosine Kinase Inhibitors
Appearance	Off-White to Pale Beige Solid
Application Notes	Genistein 7-Sulfate Sodium Salt is a derivative of Genistein (446-72-0). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.
Melting Pt.	>200C (dec.)
Boiling Pt.	No Data Available
Solubility	DMSO (Sparingly), Water
Stability	No Data Available
Storage Condition	Hygroscopic, -20C Freezer, Under inert atmosphere

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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TRC-G350045-2,5mg-safety-datasheet.pdf