MALT1 Inhibitor II,Mepazine Hydrochloride (MALT-1 Inhibitor II,Mucosa-Associated Lymphoid tissue Lymphoma Translocation 1 Inhibitor II,Pacatal,10-((1-Methylpiperidin-3-yl)methyl)-10H-phenothiazine,Hydrochloride,10-((1-Me

Blue Ice

346, 1

Supplied as a grayish to off-white powder.

A cell-permeable phenothiazine that that inhibits MALT1, but not caspase-3 or -8, proteolytic activity (IC50 = 0.83 and 0.42uM, respectively, against full-length or paracaspase domain-catalyzed Ac-LRSR-AMC hydrolysis) in a reversible and noncompetitive manner. Shown to suppress ABC-DLBCL constitutive cellular MALT1 activity (by >75% at 10uM; IC50 <5uM in U2932, OCI-Ly10, OCI-Ly3, HBL1, and TMD8 cultures) and RelB cleavage, resulting in ABC-DLBCL-selective cytotoxicity (≥27% cell death in 4 days at 10uM) over GCB-DLBCL (≤26% cell death in 4 days at 20uM) both in cultures in vitro and in mice (400ug/kg daily i.p.) in vivo.

Synonyms:
10-((1-Methylpiperidin-3-yl)methyl)-10H-phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidyl)methyl)phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidinyl)methyl)-10H-phenothiazine, Hydrochloride, MALT-1 Inhibitor II, Mucosa-Associated Lymphoid tissue Lymphoma Translocation 1 Inhibitor II, Pacatal

CAS No:
60-89-9

Solubility:
DMSO or H2O

Molecular Formula:
C₁₉H₂₃ClN₂S • x HCl

NMR:
Conforms

Carbon:
As Reported

Hydrogen:
As Reported

Nitrogen:
As Reported

Sulfur:
As Reported

LC-MS:
As Reported

Water by CHN (mol):
As Reported

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

MALT1 Inhibitor II, Mepazine Hydrochloride (MALT-1 Inhibitor II, Mucosa-Associated Lymphoid tissue Lymphoma Translocation 1 Inhibitor II, Pacatal, 10-((1-Methylpiperidin-3-yl)methyl)-10H-phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidyl)methyl)