Neuropeptide Y3 Receptor, Human, Control Peptide (NPY 3R)

Molecular Biology / MB-Receptors

-20°C

Supplied as a lyophilized powder from PBS, 0.05% sodium azide.

Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. NPY a 97aa peptide in mouse, human (chr 7p15.1) and 98aa in rat has a mol. wt of 11kD. NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in amino acid and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36aa mature peptide characterized by a hairpin loop. NPY3R/ CXCR4/ LSTR/ Fusin/ Chemokine, a 359aa protein in mouse, rat and 352 in human (chr 2q21), it shows 21% identity to NPY1R, they may help in activation of inflammatory cells.

Source:
16aa peptide from Human NPY3R (1)

Location:
~C-terminus, Cytoplasmic domain

Species Sequence Homology:
Monkey, mouse, rat-100%.

Applications:
Suitable for use in ELISA as a control peptide for N2176-64. Other applications not tested.

Recommended Dilution:
ELISA: Coat ELISA plates at 1ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.