Tyrosine Kinase, Non Receptor 2 / ACK1 (TNK2) Antibody

Tyrosine Kinase, Non Receptor 2 / ACK1 (TNK2)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

TNK2 Antibody is a Rabbit Polyclonal antibody against TNK2. This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.

TNK2

Purified by affinity chromatography.