Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody

Splicing Factor Proline And Glutamine Rich (SFPQ)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

SFPQ Antibody is a Rabbit Polyclonal antibody against SFPQ. SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. Catalog# 15585-1-AP is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

SFPQ

Purified by affinity chromatography.