Egl Nine Homolog 1 (EGLN1) Antibody

Egl Nine Homolog 1 (EGLN1)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

EGLN1 Antibody is a Rabbit Polyclonal antibody against EGLN1. The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

EGLN1

Purified by affinity chromatography.