Cytochrome B-245 Heavy Chain (CYBB) Antibody

Cytochrome B-245 Heavy Chain (CYBB)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

Cytochrome B-245 Heavy Chain (CYBB) Antibody is a Rabbit Polyclonal antibody against CYBB. Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008].

PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol.

CYBB

Purified by affinity chromatography.