G Protein Pathway Suppressor 2 (GPS2) Antibody

G Protein Pathway Suppressor 2 (GPS2)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

GPS2 Antibody is a Rabbit Polyclonal antibody against GPS2. This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol.

GPS2

Purified by affinity chromatography.